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KMID : 1189320180120050919
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Asian Spine Journal
2018 Volume.12 No. 5 p.919 ~ p.926
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Prognosis of Single Spinal Metastatic Tumors: Predictive Value of the Spinal Instability Neoplastic Score System for Spinal Adverse Events
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Chang Sam-Yeol
Ha Jae-Hong
Seo Sang-Gyo
Chang Bong-Soon
Lee Choon-Ki
Kim Hyoung-Min
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Abstract
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Study Design: This was a retrospective cohort study.
Purpose: We evaluated the predictive value of the Spinal Instability Neoplastic Score (SINS) system for spinal adverse events (SAEs) in patients with single spinal metastatic tumor.
Overview of Literature: The SINS system was developed to assess spinal instability in patients with single metastatic spinal tumor. However, the system’s potential predictive value for SAEs has been partially studied.
Methods: This system was applied to a retrospective cohort of 78 patients with single spinal metastatic tumors. The patients underwent surgical treatment and were postoperatively followed up for at least 2 years or until death. The attribution of each score and total SINS to SAE (vertebral compression fracture [VCF] and spinal cord compression [SCC]) occurrence was assessed using the Cox proportional hazards model.
Results: SAEs occurred on average 7 months after diagnosis of spinal metastasis. The mean survival rate post diagnosis was 43 months. Multivariate analysis using the Cox proportional hazards model revealed that the pain (p=0.029) and spinal alignment (p=0.001) scores were significantly related to VCF occurrence, whereas the pain (p=0.008) and posterolateral involvement (p=0.009) scores were related to SCC occurrence.
Conclusions: Among the components of the SINS system, while pain and spinal alignment showed a significant association with VCF occurrence, pain and posterolateral involvement showed association with SCC occurrence.
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KEYWORD
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Neoplasm metastasis, Spinal Instability Neoplastic Score, Compression fractures, Spinal cord compression
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